| Jacob's Protocols |
| PHASE 1-Course 1 |
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| Cycle 1 Decmeber 26-28 2003 Carboplatin Etoposide Carboplatin and Etopiside 3 hours day 1, Etopiside 2 hours day 2 & 3 Cycle 2 January 14-2004 Carboplatin Doxorubicin Cyclophosphamide given over 3.5 hours (overnight stay) Cycle 3 February 6-8 2004 Etoposide Cyclophosphamide Etopisdie and Cyclophosimide 3 hours day 1, Etopiside 2 hours day 2 & 3 Cycle 4 February 25-27 2004 Carboplatin Etoposide Doxorubicin Carboplatin, Etopiside, Doxorubicin 3.5 hours day 1, Etopiside 2 hours day 2 & 3 All scans and tests re-done after the 4th Cycle |
| PHASE 1-Course 2 |
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| Cycle 5 March 19-21 2004 Cyclophosphamide Etoposide Cyclophosphamide and Etoposide 3 hours day 1, Etoposide 2 hours day 2 & 3 Cycle 6 April 13-2004 Carboplatin Cyclophosphamide Doxorubicin given over 3.5 hours (overnight stay) Cycle 7 May 3-5 2004 Carboplatin Etoposide Carboplatin and Etoposide 3 hours day 1, Etoposide 2 hours day 2 & 3 Cycle 8 May 25-27 2004 Cyclophosphamide Doxorubicin given over 2 hours (overnight stay) All scans and tests re-done after the 8th Cycle |
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| Home |
| When Jacob receives his Chemotherapy treatments his port-a-cath is accessed and he has to 'hydrate' with IV fluids 2 hours prior to the start of his Chemotherapy and also must 'hydrate' after the treatments for up to 12 hours to flush his kidneys. He is also given Mesna which is given through the IV when he receives Cyclophosphamide to ensure that his kidneys are flushed (the Cyclophosphamide can cause Kidney damage). With his overnight treatments he is admitted in the morning and is usually discharged the following day around noon. When he has to receive 3 day treatments we are admitted in the morning on day 1 and are discharged on day 3 usually by supper time after his flush. |
| For more information on Jacob's Chemotherapy Drugs and their side effects please click on the individual drugs listed below... |
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| Neuroblastoma |
| Opsoclonus-Myoclonus Syndrome |
| PHASE 2 |
| Cycle 1 June 22-24 IVIG Prednisone IVIG administered over four hours for 2 days. Prednisone 12.5mg twice daily for one month Cycle 2 July 12-13 IVIG Cyclophosimide Prednisone IVIG administered over four hours, Cyclophosimide over 1 hour. Prednisone 12.5mg twice daily for another month Cycle 3 August 9-10 IVIG Cyclophosimide Prednisone IVIG administered over 4 hours, Cyclophosimide over 1 hour. Prednisone 17.5mg Cycle 4 September 5-6 IVIG Cyclophosimide Prednisone IVIG administered over 4 hours, Cyclophosimide over 1 hour. Prednisone 15mg Cycle 5 October 4-5 IVIG Cyclophosimide Prednisone IVIG administered over 4 hours, Cycloohosimide over 1 hour. Prednisone 12.5mg October 22-Jacobs starts on 12 week antibiotic treatment (6 IV antibiotic/6 oral antibiotics) for a bone infection Cycle 6-November 1-2 IVIG Cyclophosphamide Prednisone IVIG administered over 4 hours, Cyclophosphamide over 1 hour, prenisone 12.5mg Cycle 7-November 29-30 IVIG Cyclophosphamide Prednisone IVIG administered over 4 hours, Cyclophosphamide over 1 hour, prednisone 12.5mg Cycle 8-January 6, 2005 IVIG, Prednisone IVIG administered over 4 hours, prednisone 12.5mg every other day Cycle 9-January 31, 2005 IVIG, prednisone IVIG administered over 4 hours, Prednisone 12.5mg every other day Cycle 10-February 28, 2005 IVIG, Prednisone IVIG administered over 4 hours, Prednisone 12.5mg every other day Cycle 11-March 21, 2005 IVIG, Prednisone IVIG administered over 4 hours, prednisone 12.5mg every other day Cycle 12-April 11, 2005 IVIG, Prednisone IVIG administered over 4 hours, Prednisone 12.5mg every other day April 19th-start ACTH Protocol: 40 units twice daily until May 3rd 40 units once daily May 3rd-June 13th 40 units every other day June 13th-October 4th 30 units every other day Oct 4th-18th 20 units every other day Oct 18th-November 1st 10 untis every other day Nov 1st-15th Nov 9th-increased back to 20 units (Jacob starts to pass out) November 11-25thdecreased to 15 untis every other day November 25th-Dec 13th-decreased to 10 units every other day December 13th-27th-7.5 units every other day January 5th-restarted ACTH at 20 units due to relapse January 19th-increased to 40 units daily Jacob not responding to treatment Cycle 13-24-May 2-December 27th IVIG administered every 3 weeks for 4 hours December 27th-Jacob goes into the Pediatric Unit in Sudbury for and emergency infusion of IVIG-he has an anaphalactic reaction within minutes (his face swells and his body is covered in hives) Cycle 24 (again) Jan 6, 2006 5% solution of IVIG and a different brand are given on the Pediatric floor and the infusion goes well Feb 1st-Spinal Tap with Dr Pranzatelli in Springfield, IL, to determine our next treatment Protocol |